CASE REPORT: PATIENTS WITH POSITIVE HER-2 AMPLIFICATION LOCALLY ADVANCED GASTROESOPHAGEAL JUNCTION CANCER ACHIEVED PATHOLOGIC COMPLETE RESPONSE WITH THE ADDITION OF PEMBROLIZUMAB TO CHEMOTHERAPY PLUS TRASTUZUMAB AS NEOADJUVANT THERAPY

BackgroundHuman epidermal growth factor receptor 2(HER-2) is the most prominent therapeutic target COLOR SEALER for gastric (G)/gastroesophageal junction (GEJ) cancer.Guidelines recommend its use for treating G/GEJ cancers.However, targeted therapy did not significantly improve survival outcomes compared to those with neoadjuvant therapy.The KEYNOT

Abstract Background Lung dysfunction commonly occurs after cardiopulmonary bypass (CPB).Randomized evidence suggests that the presence of expiratory flow limitation (EFL) in major abdominal surgery is associated with postoperative pulmonary complications.Appropriate lung recruitment and a correctly set positive end-expiratory pressure (PEEP) level

This paper investigates object-based and action-based iconic strategies and combinations of them to refer to everyday objects in the lexicon of an emerging village sign language, namely Central Taurus Sign Language (CTSL) of Turkey.CTSL naturally emerged in the absence of an accessible language model within the Tees last half century.It provides a

BackgroundThe improvement in survival of preterm infants is accompanied by an increase in neonatal intensive care unit (NICU) admissions.Prolonged length of stay in the NICU (LOS-NICU) increases the incidence of neonatal complications and even mortality and places a significant economic burden on families and strain on healthcare systems.This revie